Technology Transfer and Scale-Up of a High-Density E. coli Fermentation from a 200 L Stainless Steel to a 1,000 L Single-Use Fermenter

Posted on by Debbie Hill

While single-use systems are common in mammalian cell culture, their adoption in microbial fermentation has been slower due to the high demands of oxygen transfer and cooling. ABEC’s Custom Single Run (CSR®) technology

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  • 20+ years at GSK, leading R&D activities on multiple vaccine programs
  • Recently held positions in industry include: Senior Director (Function Head), Protein Biochemistry; Director, Antigen Design & Prototype Production; and, Associate Director, Antigen Design and Protein Characterization.
  • Key areas of expertise are:
    • Process development of protein Biologics/Recombinant Antigens
    • Recombinant protein expression (mammalian, insect, yeast, bacterial)
    • Production/design of Viral Vectors, mRNA vaccines, Bacterial outer membrane vesicles
    • Protein Engineering and Structural Biology
    • Defining quality attributes, biophysical characterization of proteins, and analytical strategy
  • Post graduate degrees in Functional Genomics (Université Laval) and Bioinformatics (MIT); M. Sc. Microbiology and Immunology (Laval).
  • 25+ Patent & 5 Scientific Publications