BioVectra - Facilities



	August 29, 2011 Dale Zajicek appointed President of BioVectra Inc.... read more April 19, 2011 Doe & Ingalls and BioVectra Expand Partnership To Better Serve Biotech Companies... read more January 14, 2011 BioVectra Expansion of cGMP Contract Fermentation Capacity Nears Completion... read more


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Facilities

	API Facility Commissioned 2002 - Regis and Joan Duffy Biopharmaceutical Centre Biopharmaceutical CenterCommercial-scale manufacturing of active pharmaceutical ingredients (API's), advanced intermediates, pre-clinical and Phase I, II and III clinical trial supplies in milligram to multi-tonne quantities Ideally suited for 1-5 metric tonne volumes High-potency compound projects, cytotoxics production Commercial-scale natural product extraction/purification, small-molecule organic synthesis, and fermentation Commercial fermentation capacity to 25,000 liters 33,500 square foot, modular plant design expandable to four times initial manufacturing capacity Normal- and reverse-phase, size-exclusion, and ion-exchange commercial-scale chromatography Isolated reactor suite contains two (2) 4000 Liter glass-lined steel reactors on two floors, with an operating temperature range of -30°C to 150°C Initial reactor volume of 8,000 liters, expandable to 64,000 liters USP Purified Water System Three (3) product isolation suites for blending, milling and drying operations. Each suite can be maintained as a Class 100,000 Clean Room. Segregation of the blending, milling and drying operations are maintained by air lock separation from the other production suites and corridors Process area is rated for Electrical Hazard Class I Div I and II, allowing for the use of Class 1B liquids Plant designed/operated to meet cGMP and environmental requirements On site waste treatment BioChem Facility Commissioned 1991 - Douglas J. Hennessy Biochemical Centre Biochemical Center 20,000 square feet of manufacturing space Fine chemical synthesis and natural product extraction Glass-lined and stainless steel reactor systems from 30-1000 gallon Research and pilot scale fermentation from shake flask to 20 liter scale Filtration/centrifugation Column chromatography Drying/lyophilization Utilities include steam (120 psig), nitrogen, pressurized air, vacuum (to 0.05 mm Hg), deionized water, coolant (to -30°C) Distillation and solvent recovery Bulk solvent storage Bioextraction Facility Refitted for animal biomass processing in 2002 7 gallon Tantalum reactor, fully instrumented for process control 10 gallon glass-lined Pfaudler reactor system 30 gallon glass-lined Pfaudler reactor system Solids isolation equipment (filters, centrifuge) Column chromatography Wiped film evaporator (1 square foot) Rotary vacuum dryer (10 cubic feet)